Both sides played with many fouls, with Frankfurt playmaker Filip Kostic unable to continue after a foul from Jordan Torunarigha only 15 minutes into the match.
In the 40th minute, SIPG was awarded a penalty as Hulk's free kick hit the arm of Guoan midfielder Li Ke. The Brazilian striker converted the penalty to help the Shanghai side lead 1-0.
Valencia's 4-2 win at home to Levante a week ago was a morale boost to a club that has internal problems and lost key players over the summer. However, Javi Gracia's side received a reality check on Saturday when they were outplayed by Celta Vigo, who beat them 2-1 with two goals from club captain Iago Aspas.
In Rio de Janeiro, Botafogo recorded their seventh draw in 10 matches this season after a goalless affair with Santos at the Olympic stadium. The result left Botafogo 18th and Santos seventh.
The match was decisive to both teams, as only two rounds were left in the first phase. Sierra Leone striker Buya Turay broke the deadlock for Hebei in the 7th minute with a volley from a cross by Marcao.
The match will be played at Defensores del Chaco stadium in Asuncion on October 8, kicking off at 7:30pm local time, the entity said in a statement on its official website.
Chongqing nearly scored their third before the break when Fernandinho got an exquisite pass from Adrian, but his shot hit the post.
Leverkusen had the last chance on target but substitute and new arrival Patrik Schick was unable to beat Casteels with a header with seven minutes to the final whistle.
In Friday's only other fixture, Bolivia's Jorge Wilstermann secured a 3-0 home win over Uruguayan side Penarol. Enditem
Leeds began their Premier League campaign with a 4-3 defeat away to Liverpool. Last weekend, the team coached by Marcelo Bielsa beat Fulham 4-3.
Matthew Wolff of the United States came second at even par and South Africa's Louis Oosthuizen was third on 282.